Pharmacokinetics of oleandomycin administered alone and after oral ascorbic acid in three bird species

The influence of ascorbic acid administration via drinking water at a dose of 15 mg/l over a period of 7 days on the pharmacokinetics of oleandomycin in chickens, musk ducks and Japanese quails was investigated. After ascorbic acid oleandomycin elimination, half-life was longer. Oleandomycin bioavailability in chickens and quails after per os application was increased with ascorbic acid. Interspecies differences in oleandomycin body disposition were observed. Lower elimination rate constants were obtained in the musk ducks in comparison with two other species. The volume of distribution (Vss) was larger in quails. In conclusion, ascorbic acid did not change oleandomycin disposition significantly in the treated birds.